REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION

Abstract

The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be extrapolated to monocytic cells of origin of mammals. It is indicated that Hantaviruses are resistant to the effects of monocytes/macrophages and are capable of intracellular replication in them breaking thus the biological barrier preventing the spread of the pathogen from the primary site of infection and protects against infected sensitive cells of various organs. With respect of neutrophils revealed that hantavirus showing cytopathogenic properties, as indicated by the appearance of apoptotic cells and modified periods of reduced viability of the cell culture.

Keywords

• monocytes
• macrophages
• neutrophils
• viral infection
• ultrastructure
• metabolism of cell