Study on indicators of diabetic nephropathy

Abstract

Background: Microalbuminuria, serum creatinine, albumin/ creatinine ratio & eGFR are currently in use for early changes in DN. Serum SA levels correlate positively with albuminuria which is indicator for DN, hence serum levels are raised even before clinical nephropathy is diagnosed. An elevation in the serum SA concentration has been observed in DN in the study conducted by Jarkko Romppanen. Thus research was undertaken to study indicators of DN like SA, HbA1c, lipid profile, Serum Creatinine & Urine albumin/ Creatinine ratio. Objectives: To estimate levels of Serum SA, HbA1c, Lipid profile, Serum Creatinine & Urine albumin/Creatinine ratio in type 2 DM & DN patients. Methods: Serum SA by resorcinol-HCl-Copper reagent method, Glycated Hb by Ion exchange resin method, Lipid profile by enzymatic method, Serum Creatinine by Jaffe’s method, Urine albumin/ creatinine ratio (UAC)- Urine albumin & creatinine by Immuno-turbidometry. Results: Serum SA concentration significantly increased in DN when compared to DM and positively co-related with other factors like glycemic control (HbA1c), lipid profile, Serum creatinine & UAC. Hence, serum SA levels could be used as early indicator of DN. Conclusion: SA levels in DN were increased & statistically significant when compared to DM without nephropathy. The mean HbA1c, TC, triglyceride, LDL, serum creatinine, & urine A/C ratio were significantly increased & were correlated positively with SA.

Keywords

• sa- sialic acid
• dn- diabetic nephropathy
• hba1c- glycated hemoglobin