Arterial hypertension: interrelation between heart, arterial and venous structure and function, their prognostic role in antihypertensive treatment optimization

Abstract

Aim. To investigate principal interrelations between heart, arterial and venous parameters, characterizing the common process of cardiovascular system (CVS) remodeling during arterial hypertension (AH) development and progression.Material and methods. The study included 184 patients with primary AH. CVS structure and function were assessed at baseline and after treatment with antihypertensive medications (AHM).Results. The module approach to AH structural and hemodynamic type description is proposed. Modern AHM are studied in regard to their venotropic action, effects on orthostatic tolerance and interrelations between structural and functional parameters of CVS components in AH patients. Mathematical algorithms assessing modern AHM potential for individual patients, taking into account baseline clinical, functional, structural and hemodynamic parameters, are presented.Conclusion. Antihypertensive therapy could be optimized by taking into consideration modern AHM effects on individual CVS components and their interrelations in AH patients.

Keywords

• arterial hypertension
• structural and functional interrelations
• cardiac hemodynamics
• arterial system
• venous vessels
• antihypertensive therapy