Injection site acanthosis nigricans in type 1 diabetes mellitus and hepatocellular carcinoma: A case report

Abstract

Many injection site cutaneous complications such as lipohypertrophy and atrophy are known to occur in type 1 diabetic individuals. Acanthosis nigricans (AN) with insulin injection is a rare complication described in few case reports. It is also described as a paraneoplastic manifestation of malignancies such as hepatocellular carcinoma (HCC). Here we describe a case of injection site acanthosis in a type 1 diabetic with underlying HCC. This case report highlights the importance of knowledge on proper injection technique to prevent such unfortunate complications. High degree of suspicion of underlying malignancies is warranted in atypical presentation of AN.

Keywords

• acanthosis nigricans
• cutaneous complications
• hepatocellular carcinoma
• type 1 diabetes mellitus