Chemoreactome modeling the effects of anions of lithium salts ascorbate, nicotinate, hydroxybutyrate komenata and lithium carbonate

Abstract

The estimates of the neurophysiological, pharmacokinetic, hemodynamic and anti-inflammatory properties of ascorbate anion were obtained. In comparison with the control molecules (nicotinate, oxybutyrate, comenate, carbonate) ascorbate anion has characteristically higher affinity for serotonin, dopamine, benzodiazepine, adrenergic receptors. Higher affinity for human benzodiazepine receptor indicates possible anxiolytic effects of ascorbate. Ascorbate anion can be characterized by a strong antioxidant and anti-inflammatory effect caused by modulation of prostaglandin metabolism. Ascorbate anion can also exhibit anticoagulant, antihyperglycemic and antihyperlipidemic effects. Chemoreactome simulation results also indicated that carbonate anion has none of the aforementioned properties of ascorbate anion.

Keywords

• соли лития
• аскорбат лития
• хемоинформатика
• lithium
• lithium ascorbate
• cheminformatics