The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

Yang Zhao; Xiang Ye; Myriam Shehata; William Dunker; Zhihang Xie; John Karijolich

doi:10.1038/s41467-020-17151-2

Nature Communications (Jul 2020)

The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

Yang Zhao,
Xiang Ye,
Myriam Shehata,
William Dunker,
Zhihang Xie,
John Karijolich

Affiliations

Yang Zhao: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
Xiang Ye: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
Myriam Shehata: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
William Dunker: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
Zhihang Xie: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
John Karijolich: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center

DOI: https://doi.org/10.1038/s41467-020-17151-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral transcripts leading to inhibition of KSHV lytic reactivation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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