Nature Communications (Sep 2018)
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
- K. G. Paulson,
- V. Voillet,
- M. S. McAfee,
- D. S. Hunter,
- F. D. Wagener,
- M. Perdicchio,
- W. J. Valente,
- S. J. Koelle,
- C. D. Church,
- N. Vandeven,
- H. Thomas,
- A. G. Colunga,
- J. G. Iyer,
- C. Yee,
- R. Kulikauskas,
- D. M. Koelle,
- R. H. Pierce,
- J. H. Bielas,
- P. D. Greenberg,
- S. Bhatia,
- R. Gottardo,
- P. Nghiem,
- A. G. Chapuis
Affiliations
- K. G. Paulson
- University of Washington
- V. Voillet
- Fred Hutchinson Cancer Research Center
- M. S. McAfee
- Fred Hutchinson Cancer Research Center
- D. S. Hunter
- Fred Hutchinson Cancer Research Center
- F. D. Wagener
- Fred Hutchinson Cancer Research Center
- M. Perdicchio
- Fred Hutchinson Cancer Research Center
- W. J. Valente
- Fred Hutchinson Cancer Research Center
- S. J. Koelle
- University of Washington
- C. D. Church
- University of Washington
- N. Vandeven
- University of Washington
- H. Thomas
- University of Washington
- A. G. Colunga
- University of Washington
- J. G. Iyer
- University of Washington
- C. Yee
- MD Anderson Cancer Center
- R. Kulikauskas
- University of Washington
- D. M. Koelle
- University of Washington
- R. H. Pierce
- Fred Hutchinson Cancer Research Center
- J. H. Bielas
- University of Washington
- P. D. Greenberg
- University of Washington
- S. Bhatia
- University of Washington
- R. Gottardo
- University of Washington
- P. Nghiem
- University of Washington
- A. G. Chapuis
- University of Washington
- DOI
- https://doi.org/10.1038/s41467-018-06300-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.
