Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics

Wanli Song; Pengfei Jia; Yaping Ren; Junmiao Xue; Bingqian Zhou; Xinkai Xu; Yansheng Shan; Jing Deng; Qihui Zhou

Bioactive Materials (May 2023)

Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics

Wanli Song,
Pengfei Jia,
Yaping Ren,
Junmiao Xue,
Bingqian Zhou,
Xinkai Xu,
Yansheng Shan,
Jing Deng,
Qihui Zhou

Affiliations

Wanli Song: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Pengfei Jia: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Yaping Ren: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Junmiao Xue: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Bingqian Zhou: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Xinkai Xu: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Yansheng Shan: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Jing Deng: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China
Qihui Zhou: Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China; Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, 266003, Shandong, China; School of Stomatology, Qingdao University, Qingdao, 266003, China; Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin, 300038, China; School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266071, China; Corresponding author. Department of Stomatology, Institute for Translational Medicine, The Afﬁliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, China.

Journal volume & issue: Vol. 23
pp. 80 – 100

Abstract

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White blood cells (WBCs) play essential roles against inflammatory disorders, bacterial infections, and cancers. Inspired by nature, WBC membrane-camouflaged nanocarriers (WBC-NCs) have been developed to mimic the “dynamic” functions of WBCs, such as transendothelial migration, adhesion to injured blood vessels, etc, which make them promising for diverse medical applications. WBC-NCs inherit the cell membrane antigens of WBCs, while still exhibiting the robust inflammation-related therapeutic potential of synthetic nanocarriers with excellent (bio)physicochemical performance. This review summarizes the proposed concept of cell membrane engineering, which utilizes physical engineering, chemical modification, and biological functionalization technologies to endow the natural cell membrane with abundant functionalities. In addition, it highlights the recent progress and applications of WBC-NCs for inflammation targeting, biological neutralization, and immune modulation. Finally, the challenges and opportunities in realizing the full potential of WBC-NCs for the manipulation of inflammation-related therapeutics are discussed.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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