Natural oscillation frequencies in the two lateral prefrontal cortices induced by Transcranial Magnetic Stimulation
Antonino Vallesi,
Alessandra Del Felice,
Mariagrazia Capizzi,
Alessandra Tafuro,
Emanuela Formaggio,
Patrizia Bisiacchi,
Stefano Masiero,
Ettore Ambrosini
Affiliations
Antonino Vallesi
Department of Neuroscience & Padova Neuroscience Center, University of Padua, Padua, Italy; Brain Imaging and Neural Dynamics Research Group, IRCCS, San Camillo Hospital, Venice Italy; Corresponding author at: Department of Neuroscience & Padova Neuroscience Center, University of Padua, Padua, Italy.
Alessandra Del Felice
Section of Rehabilitation Department of Neuroscience, University of Padua, Padua, Italy; Padova Neuroscience Center, University of Padua, Padua, Italy
Mariagrazia Capizzi
Section of Rehabilitation Department of Neuroscience, University of Padua, Padua, Italy
Alessandra Tafuro
Padova Neuroscience Center, University of Padua, Padua, Italy
Emanuela Formaggio
Section of Rehabilitation Department of Neuroscience, University of Padua, Padua, Italy; Padova Neuroscience Center, University of Padua, Padua, Italy
Patrizia Bisiacchi
Padova Neuroscience Center, University of Padua, Padua, Italy; EA 4556 EPSYLON, Université Paul Valéry, Montpellier 3, France
Stefano Masiero
Section of Rehabilitation Department of Neuroscience, University of Padua, Padua, Italy; Padova Neuroscience Center, University of Padua, Padua, Italy
Ettore Ambrosini
Padova Neuroscience Center, University of Padua, Padua, Italy; Department of Neuroscience, University of Padua, Padua, Italy; Department of General Psychology, University of Padua, Padua, Italy
Different cortical regions respond with distinct rhythmic patterns of neural oscillations to Transcranial Magnetic Stimulation (TMS). We investigated natural frequencies induced by TMS in left and right homologous dorsolateral prefrontal cortices (DLPFC) and related hemispheric differences. In 12 healthy young adults, single-pulse TMS was delivered in different blocks close to F3 and F4 channels to target left and right DLPFC. An occipital site near PO3 was stimulated as control. TMS-related spectral perturbation analyses were performed on recorded EEG data. A widespread unspecific increase in theta power was observed for all stimulation sites. However, occipital TMS induced greater alpha activity and a 10.58 Hz natural frequency, while TMS over the left and right DLPFC resulted in similar beta band modulations and a natural frequency of 18.77 and 18.5 Hz, respectively. In particular, TMS-related specific increase in beta activity was stronger for the right than the left DLPFC. The right DLPFC is more specifically tuned to its natural beta frequency when it is directly stimulated by TMS than with TMS over the left counterpart (or a posterior region), while the left DLPFC increases its beta activity more similarly irrespective of whether it is directly stimulated or through right homologous stimulation. These results yield important implications for both basic neuroscience research on inter-hemispheric prefrontal interactions and clinical applications.
