Nature Communications (Aug 2019)

Virus lasers for biological detection

  • John E. Hales,
  • Guy Matmon,
  • Paul A. Dalby,
  • John M. Ward,
  • Gabriel Aeppli

DOI
https://doi.org/10.1038/s41467-019-11604-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Many ligand-binding assays still rely on signals that scale linearly with probe concentration. The authors present lasing detection probes with a dye-labelled virus as the gain medium to optically amplify the signal, which could enable much higher signals than for fluorescent quantification.