Frontiers in Microbiology (Jan 2023)

Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

  • Jicheng Han,
  • Jicheng Han,
  • Xiangyu Zhu,
  • Xiangyu Zhu,
  • Zihan Gao,
  • Zihan Gao,
  • Yan Xiao,
  • Yan Xiao,
  • Jinxin Zhang,
  • Jinxin Zhang,
  • Peng Wang,
  • Peng Wang,
  • Jinbo Fang,
  • Yiquan Li,
  • Yilong Zhu,
  • Yue Li,
  • Yue Li,
  • Ningyi Jin,
  • Ningyi Jin,
  • Huijun Lu,
  • Dazhuan Lin,
  • Wenshen Liu

DOI
https://doi.org/10.3389/fmicb.2022.1067725
Journal volume & issue
Vol. 13

Abstract

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Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.

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