HLH-11 modulates lipid metabolism in response to nutrient availability

Yi Li; Wanqiu Ding; Chuan-Yun Li; Ying Liu

doi:10.1038/s41467-020-19754-1

Nature Communications (Nov 2020)

HLH-11 modulates lipid metabolism in response to nutrient availability

Yi Li,
Wanqiu Ding,
Chuan-Yun Li,
Ying Liu

Affiliations

Yi Li: State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University
Wanqiu Ding: Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking University
Chuan-Yun Li: Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking University
Ying Liu: State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University

DOI: https://doi.org/10.1038/s41467-020-19754-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Organismal metabolism fluctuates depending on nutritional conditions. Here, the authors show that, in C. elegans, HLH-11 negatively regulates lipid metabolism genes in the presence of nutrients and that its abundance decreased in response to starvation, thereby promoting fat utilization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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