The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies

Abstract

Qiu-Yue Peng,1– 3,* Ying An,1– 3,* Zong-Zhe Jiang,1– 3 Yong Xu1– 3 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan, People’s Republic of China; 3Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Xu; Zong-zhe Jiang, Email [email protected]; [email protected]: Diabetic kidney disease (DKD), is a common microvascular complication and a major cause of death in patients with diabetes. Disorders of immune cells and immune cytokines can accelerate DKD development of in a number of ways. As the kidney is composed of complex and highly differentiated cells, the interactions among different cell types and immune cells play important regulatory roles in disease development. Here, we summarize the latest research into the molecular mechanisms underlying the interactions among various immune and renal cells in DKD. In addition, we discuss the most recent studies related to single cell technology and bioinformatics analysis in the field of DKD. The aims of our review were to explore immune cells as potential therapeutic targets in DKD and provide some guidance for future clinical treatments.Keywords: diabetic kidney disease, immune cells, bioinformatics analysis, single-cell analysis

Keywords

• diabetic kidney disease
• immune cells
• bioinformatics analysis
• single-cell analysis