FEATURES OF ULTRASOUND PARAMETERS AND MARKER OF ANGIOGENESIS IN PATIENTS WITH RHEUMATOID ARTHRITIS DEPENDING OF THE LEVEL ANTI-CCP

Abstract

Purpose: to study features of ultrasound parameters of the joints and vascular endothelial growth factor (VEGF) in patients with rheumatoid arthritis, depending of the level of antibodies to cyclic citrullinated peptide (anti-CCP) in the blood.Materials and Methods: 155 patients with rheumatoid arthritis joints had done ultrasound with Doppler of the joints, the levels of anti-CCP and VEGF in the blood - ELISA. The patients were divided into two group: 1st gr. - patients with negative or low positive level of anti-CCP ( ≤ 40 IU/ml) in the blood, 2nd gr. patients with highly positive level of anti-CCP ( > 40 IU/ml).Results: In patients with anti-CCP levels > 40 IU/ml were to increase the level of VEGF in 1.5 times, higher effusion of joints, angiogenesis (vascularization of synovium in 2 times was more likely gradation 2-3 points), were more tendosynovitis and erosions compared with patients with low levels of anti-CCP.Conclusion: the concentration of VEGF in the blood, the intensity of synovial angiogenesis, effusion in the cavity of joint, tendosynovitis and erosion were to increase with had been increasing levels of anti-CCP in the blood.

Keywords

• rheumatoid arthritis
• angiogenesis
• vascular endothelial growth
• antibodies to cyclic citrullinated peptide