The recent advance and prospect of natural source compounds for the treatment of heart failure
Xing-Juan Chen,
Si-Yuan Liu,
Si-Ming Li,
Ji-Kang Feng,
Ying Hu,
Xiao-Zhen Cheng,
Cheng-Zhi Hou,
Yun Xu,
Mu Hu,
Ling Feng,
Lu Xiao
Affiliations
Xing-Juan Chen
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China
Si-Yuan Liu
Beijing University of Chinese Medicine, Beijing, 100029, China
Si-Ming Li
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China
Ji-Kang Feng
Linyi Zhengzhi Hospital, Linyi, 276004, China
Ying Hu
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China
Xiao-Zhen Cheng
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China
Cheng-Zhi Hou
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China
Yun Xu
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China
Mu Hu
Peking University International Hospital, Beijing, 102206, China
Ling Feng
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China; Corresponding author.
Lu Xiao
China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, 100053, China; Corresponding author.
Heart failure is a continuously developing syndrome of cardiac insufficiency caused by diseases, which becomes a major disease endangering human health as well as one of the main causes of death in patients with cardiovascular diseases. The occurrence of heart failure is related to hemodynamic abnormalities, neuroendocrine hormones, myocardial damage, myocardial remodeling etc, lead to the clinical manifestations including dyspnea, fatigue and fluid retention with complex pathophysiological mechanisms. Currently available drugs such as cardiac glycoside, diuretic, angiotensin-converting enzyme inhibitor, vasodilator and β receptor blocker etc are widely used for the treatment of heart failure. In particular, natural products and related active ingredients have the characteristics of mild efficacy, low toxicity, multi-target comprehensive efficacy, and have obvious advantages in restoring cardiac function, reducing energy disorder and improving quality of life. In this review, we mainly focus on the recent advance including mechanisms and active ingredients of natural products for the treatment of heart failure, which will provide the inspiration for the development of more potent clinical drugs against heart failure.
