A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans

Matthew Z. Anderson; Gregory J. Thomson; Matthew P. Hirakawa; Richard J. Bennett

doi:10.1038/s41467-019-12376-2

Nature Communications (Sep 2019)

A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans

Matthew Z. Anderson,
Gregory J. Thomson,
Matthew P. Hirakawa,
Richard J. Bennett

Affiliations

Matthew Z. Anderson: Department of Microbiology, The Ohio State University
Gregory J. Thomson: Department of Molecular Microbiology and Immunology, Brown University
Matthew P. Hirakawa: Department of Molecular Microbiology and Immunology, Brown University
Richard J. Bennett: Department of Molecular Microbiology and Immunology, Brown University

DOI: https://doi.org/10.1038/s41467-019-12376-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Mating of Candida albicans produces tetraploid products that return to the diploid state via a non-meiotic process known as concerted chromosome loss (CCL). Here, Anderson et al. show high recombination rates during CCL and identify factors that are essential for chromosome stability and recombination during CCL.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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