Nature Communications (Sep 2020)
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
- Jian-Wei Hao,
- Juan Wang,
- Huiling Guo,
- Yin-Yue Zhao,
- Hui-Hui Sun,
- Yi-Fan Li,
- Xiao-Ying Lai,
- Ning Zhao,
- Xu Wang,
- Changchuan Xie,
- Lixin Hong,
- Xi Huang,
- Hong-Rui Wang,
- Cheng-Bin Li,
- Bin Liang,
- Shuai Chen,
- Tong-Jin Zhao
Affiliations
- Jian-Wei Hao
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Juan Wang
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Huiling Guo
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Yin-Yue Zhao
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Hui-Hui Sun
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Yi-Fan Li
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Xiao-Ying Lai
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Ning Zhao
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Xu Wang
- Institute of Metabolism and Integrative Biology, Fudan University
- Changchuan Xie
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Lixin Hong
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Xi Huang
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Hong-Rui Wang
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Cheng-Bin Li
- Center for Life Sciences, School of Life Sciences, Yunnan University
- Bin Liang
- Center for Life Sciences, School of Life Sciences, Yunnan University
- Shuai Chen
- State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University
- Tong-Jin Zhao
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-020-18565-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The mechanistic details of fatty acid uptake into cells remains poorly understood. Here, the authors identify CD36 internalization via cavaeolae and demonstrate dynamic palmitoylationof CD36 is required for endocytic uptake of fatty acids.
