Nature Communications (Sep 2020)

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

  • Jian-Wei Hao,
  • Juan Wang,
  • Huiling Guo,
  • Yin-Yue Zhao,
  • Hui-Hui Sun,
  • Yi-Fan Li,
  • Xiao-Ying Lai,
  • Ning Zhao,
  • Xu Wang,
  • Changchuan Xie,
  • Lixin Hong,
  • Xi Huang,
  • Hong-Rui Wang,
  • Cheng-Bin Li,
  • Bin Liang,
  • Shuai Chen,
  • Tong-Jin Zhao

DOI
https://doi.org/10.1038/s41467-020-18565-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The mechanistic details of fatty acid uptake into cells remains poorly understood. Here, the authors identify CD36 internalization via cavaeolae and demonstrate dynamic palmitoylationof CD36 is required for endocytic uptake of fatty acids.