Nature Communications (Nov 2017)
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
- Herbert Schulz,
- Ann-Kathrin Ruppert,
- Stefan Herms,
- Christiane Wolf,
- Nazanin Mirza-Schreiber,
- Oliver Stegle,
- Darina Czamara,
- Andreas J. Forstner,
- Sugirthan Sivalingam,
- Susanne Schoch,
- Susanne Moebus,
- Benno Pütz,
- Axel Hillmer,
- Nadine Fricker,
- Hartmut Vatter,
- Bertram Müller-Myhsok,
- Markus M. Nöthen,
- Albert J. Becker,
- Per Hoffmann,
- Thomas Sander,
- Sven Cichon
Affiliations
- Herbert Schulz
- Cologne Center for Genomics, University of Cologne
- Ann-Kathrin Ruppert
- Cologne Center for Genomics, University of Cologne
- Stefan Herms
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Christiane Wolf
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Nazanin Mirza-Schreiber
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Oliver Stegle
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Darina Czamara
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Andreas J. Forstner
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Sugirthan Sivalingam
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Susanne Schoch
- Department of Neuropathology, University of Bonn Medical Center
- Susanne Moebus
- Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen
- Benno Pütz
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Axel Hillmer
- Genome Institute of Singapore
- Nadine Fricker
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Hartmut Vatter
- Department of Neurosurgery, University of Bonn Medical Center
- Bertram Müller-Myhsok
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Markus M. Nöthen
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Albert J. Becker
- Department of Neuropathology, University of Bonn Medical Center
- Per Hoffmann
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- Thomas Sander
- Cologne Center for Genomics, University of Cologne
- Sven Cichon
- Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn
- DOI
- https://doi.org/10.1038/s41467-017-01818-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.
