Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
Zhijun Chen,
Yanbo Liu,
Juan Huang,
Ming Hao,
Xiaodong Hu,
Xiaoming Qian,
Jintu Fan,
Hongjun Yang,
Bo Yang
Affiliations
Zhijun Chen
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Yanbo Liu
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Juan Huang
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China
Ming Hao
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Xiaodong Hu
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Xiaoming Qian
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Jintu Fan
State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
Hongjun Yang
School of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, China
Bo Yang
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China
In this paper, near-field direct-writing melt electrospinning technology was employed to fabricate a polycaprolactone/nano-hydroxyapatite (PCL/nHA) scaffold for future applications in tissue engineering. The influences of different fabrication parameters on the structural characteristics, mechanical properties, and thermal stability of the scaffolds were discussed. It was found that the moving speed of the receiving plate had the most significant effect on the scaffold performance, followed by the receiving distance and spinning voltage. The results also showed that these process parameters affected the fiber diameter, corresponding coefficient of variation, porosity of the composite scaffolds, and mechanical properties of the samples, including the tensile strength and fiber peeling strength. Moreover, the process parameters could influence the thermal degradation performance and melting process. Although the mass loss of the composite scaffolds was not obvious after degradation, the mechanical performance degraded severely. It was concluded that the more appropriate process parameters for preparing PCL/nHA scaffolds were a spinning voltage of −4 kV, receiving distance of 4 mm, moving speed of receiving plate of 5 mm/s, and melt temperature of 130 °C. This study proved that near-field direct-writing melt electrospinning technology is a good method to obtain PCL/nHA composite scaffolds with an excellent mechanical properties and desired morphology for future tissue engineering applications.
