Nature Communications (Aug 2019)

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

  • Yuwen Li,
  • Xiaodan Ma,
  • Zhiming Chen,
  • Haiyan Wu,
  • Pengran Wang,
  • Wenyu Wu,
  • Nuo Cheng,
  • Longhui Zeng,
  • Hao Zhang,
  • Xun Cai,
  • Sai-Juan Chen,
  • Zhu Chen,
  • Guoyu Meng

DOI
https://doi.org/10.1038/s41467-019-11746-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes promyelocytic leukemia leukemogenesis in transgenic mice.