Nature Communications (Mar 2021)
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
- Baotong Zhang,
- Yixiang Li,
- Qiao Wu,
- Lin Xie,
- Benjamin Barwick,
- Changying Fu,
- Xin Li,
- Daqing Wu,
- Siyuan Xia,
- Jing Chen,
- Wei Ping Qian,
- Lily Yang,
- Adeboye O. Osunkoya,
- Lawrence Boise,
- Paula M. Vertino,
- Yichao Zhao,
- Menglin Li,
- Hsiao-Rong Chen,
- Jeanne Kowalski,
- Omer Kucuk,
- Wei Zhou,
- Jin-Tang Dong
Affiliations
- Baotong Zhang
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Yixiang Li
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Qiao Wu
- Department of Genetics and Cell Biology, Nankai University College of Life Sciences
- Lin Xie
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Benjamin Barwick
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Changying Fu
- Department of Genetics and Cell Biology, Nankai University College of Life Sciences
- Xin Li
- Molecular Oncology and Biomarkers Program, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University
- Daqing Wu
- Molecular Oncology and Biomarkers Program, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University
- Siyuan Xia
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Jing Chen
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Wei Ping Qian
- Winship Cancer Institute, Emory University
- Lily Yang
- Winship Cancer Institute, Emory University
- Adeboye O. Osunkoya
- Winship Cancer Institute, Emory University
- Lawrence Boise
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Paula M. Vertino
- Winship Cancer Institute, Emory University
- Yichao Zhao
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Menglin Li
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Hsiao-Rong Chen
- Department of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory University
- Jeanne Kowalski
- Department of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory University
- Omer Kucuk
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Wei Zhou
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Jin-Tang Dong
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21976-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.
