Frontiers in Bioengineering and Biotechnology (Apr 2024)
Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseases
- Yaohang Yue,
- Yaohang Yue,
- Yaohang Yue,
- Yaohang Yue,
- Yaohang Yue,
- Wei Dai,
- Wei Dai,
- Wei Dai,
- Wei Dai,
- Wei Dai,
- Yihao Wei,
- Yihao Wei,
- Yihao Wei,
- Yihao Wei,
- Siyang Cao,
- Siyang Cao,
- Siyang Cao,
- Siyang Cao,
- Shuai Liao,
- Shuai Liao,
- Shuai Liao,
- Shuai Liao,
- Aikang Li,
- Aikang Li,
- Aikang Li,
- Aikang Li,
- Peng Liu,
- Peng Liu,
- Peng Liu,
- Jianjing Lin,
- Jianjing Lin,
- Jianjing Lin,
- Jianjing Lin,
- Hui Zeng,
- Hui Zeng,
- Hui Zeng,
- Hui Zeng,
- Hui Zeng,
- Hui Zeng
Affiliations
- Yaohang Yue
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China
- Yaohang Yue
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yaohang Yue
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yaohang Yue
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yaohang Yue
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Wei Dai
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China
- Wei Dai
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Wei Dai
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Wei Dai
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Wei Dai
- Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yihao Wei
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yihao Wei
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yihao Wei
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Yihao Wei
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Siyang Cao
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Siyang Cao
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Siyang Cao
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Siyang Cao
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Shuai Liao
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Shuai Liao
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Shuai Liao
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Shuai Liao
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Aikang Li
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Aikang Li
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Aikang Li
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Aikang Li
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Peng Liu
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Peng Liu
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Peng Liu
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Jianjing Lin
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Jianjing Lin
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Jianjing Lin
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Jianjing Lin
- Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Hui Zeng
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China
- Hui Zeng
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Hui Zeng
- Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Hui Zeng
- National and Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Hui Zeng
- Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- Hui Zeng
- Shenzhen Second People’s Hospital, Shenzhen, Guangdong, China
- DOI
- https://doi.org/10.3389/fbioe.2024.1377142
- Journal volume & issue
-
Vol. 12
Abstract
Degenerative orthopaedic diseases pose a notable worldwide public health issue attributable to the global aging population. Conventional medical approaches, encompassing physical therapy, pharmaceutical interventions, and surgical methods, face obstacles in halting or reversing the degenerative process. In recent times, exosome-based therapy has gained widespread acceptance and popularity as an effective treatment for degenerative orthopaedic diseases. This therapeutic approach holds the potential for “cell-free” tissue regeneration. Exosomes, membranous vesicles resulting from the fusion of intracellular multivesicles with the cell membrane, are released into the extracellular matrix. Addressing challenges such as the rapid elimination of natural exosomes in vivo and the limitation of drug concentration can be effectively achieved through various strategies, including engineering modification, gene overexpression modification, and biomaterial binding. This review provides a concise overview of the source, classification, and preparation methods of exosomes, followed by an in-depth analysis of their functions and potential applications. Furthermore, the review explores various strategies for utilizing exosomes in the treatment of degenerative orthopaedic diseases, encompassing engineering modification, gene overexpression, and biomaterial binding. The primary objective is to provide a fresh viewpoint on the utilization of exosomes in addressing bone degenerative conditions and to support the practical application of exosomes in the theranosis of degenerative orthopaedic diseases.
Keywords
