Objectives: Implant therapy has gained wide popularity in the recent years. A complete information on implant therapy should be provided to patient by the dentist. The aim of present study is to evaluate the knowledge, attitude, source of information and acceptance of dental implants among the general population in the Southern region of Saudi Arabia.Methods: A total of 712 patients were randomly selected from the OPD of dental hospitals across the southern region of Saudi Arabia. The designed questionnaire comprised of 15 open-ended questions. Only Saudi national population was selected for the survey. The questionnaire was divided into demographic data, knowledge, attitude and participant’s acceptance towards implant therapy. The collected data were statistically analyzed using the Statistical Package for Social Sciences.Results: Out of 712 participants, 675 complete the survey. 59.1% were male and 41.9% were females with an average age of 39.6 years old. All variables except for age showed statistically significant difference in the knowledge about implant among the study groups (p<0.05). The knowledge score was directly related to education and professional status of the participants. Majority of the patients (66%) with a history of implant therapy were satisfied with the placed implant. 41% of the participants reported high cost as a limiting factor for selecting an implant treatment. Conclusions: Population from the southern region of Saudi Arabia has moderate knowledge about dental implant treatment. Dentists were found to be the most important source of information to the patient. The major barrier for not selecting implant treatment was the high cost of the implant therapy.