Retrospective Analysis of demographic and laboratory characteristics of patients with liver cirrhosis: A single center experience

Abstract

Liver cirrhosis is a progressive, irreversible disease constituted by a decrease in normal hepatocytes, diffuse fibrosis, and regeneration nodules due to liver damage developed by the chronic inflammation process. This study aims to evaluate patients with liver cirrhosis who applied to Canakkale Onsekiz Mart University (COMU) Hospital and met the criteria in terms of demographic, etiological, and laboratory values. Patient data were recorded from the hospital data recording system that was admitted to COMU hospital between January 1, 2013, and January 01, 2022. A total of 199 patients with liver cirrhosis were included in the study. Of these patients, 38.2% were female, and 61.8% were male. Their mean age was 63.43±10.73 years. When the patients were evaluated with regard to etiological distribution, the top three etiological causes of cirrhosis were cryptogenic, alcohol-induced, and HBV in 27.6%, 27.1%, and 25.1% of patients, respectively. In terms of complications, ascites were detected in 43.2% of the patients, esophageal varices in 56.3%, splenomegaly in 69.3% and hepatic encephalopathy in 7%. Over the years, the number of patients with cirrhosis due to viral hepatitis has decreased due to an increase in viral hepatitis vaccination campaigns and the spread of antiviral treatments. However, due to the rise in chronic alcohol use, alcohol appears more frequently as a significant risk factor for the etiology of liver cirrhosis. [Med-Science 2023; 12(2.000): 484-9]

Keywords

• cirrhosis
• etiology
• demographic factors
• meld score