<i>N</i>,<i>N</i>-Dimethylformamide’s Participation in Domino Reactions for the Synthesis of Se-Phenyl Dimethylcarbamoselenoate Derivatives

Abstract

N,N-dimethylformamide’s (DMF) participation in domino reactions has been developed. Starting from substituted halogenobenzenes and selenium powder, versatile biologically active Se-phenyl dimethylcarbamoselenoate derivatives were efficiently synthesized under mild reaction conditions. The reaction mechanism was studied using control experiments. These protocols involve a wider substrate scope and provide an economical approach toward C–selenium bond formation.

Keywords

• dual role
• DMF
• domino reaction
• C–selenium bond formation
• copper catalyst