Nature Communications (May 2021)

The quantitative metabolome is shaped by abiotic constraints

  • Amir Akbari,
  • James T. Yurkovich,
  • Daniel C. Zielinski,
  • Bernhard O. Palsson

DOI
https://doi.org/10.1038/s41467-021-23214-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Evolution selects for the fittest but must operate within the realm of the physically possible. Here, the authors present a theoretical framework that allows them to explore how ten abiotic constraints can shape the operation, regulation, and adaptation of metabolism in E. coli.