Toxics (Dec 2021)

Overdose of Quetiapine—A Case Report with QT Prolongation

  • Elisabetta Bertol,
  • Fabio Vaiano,
  • Antonina Argo,
  • Stefania Zerbo,
  • Claudia Trignano,
  • Simone Protani,
  • Donata Favretto

DOI
https://doi.org/10.3390/toxics9120339
Journal volume & issue
Vol. 9, no. 12
p. 339

Abstract

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Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge.

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