Proteinograma do líquido cefalorraqueano do recém-nascido normal Cerebrospinal fluid proteins in normal newborn infants

Abstract

Estudo do proteinograma do líquido cefalorraqueano lombar de 40 recém-nascidos normais com 2 dias de vida. Em relação ao proteinograma do líquido cefalorraqueano do adulto normal, os achados desta investigação demonstram maior concentração proteica e maior participação relativa no perfil proteico da albumina, da globulina alfa-1 e da globulina gama. Estes achados são próprios ao perfil de tipo transudativo, encontrado em certas condições patológicas no adulto. A incompleta maturidade funcional da barreira hêmato-liquórica ao nascimento parece ser a principal responsável pelas características do proteinograma do líquido cefalorraqueano encontradas no recém-nascido normal.The protein fractions of lumbar cerebrospinal fluid (CSF) were studied in 40 normal newborns 2 days-old. The results were compared to those found in normal adult peoples. It was shown that the relative concentrations of albumin, alpha-1 globulin, and gamma globulin are more conspicuous in the newborn than in the adult. The protein pattern in the normal newborn is similar to the transudative pattern described in the adult life in several pathologic conditions. The findings were related to the blood — CSF barrier conditions in the newborn. The incomplete functional maturity of blood — CSF barrier at this time of the life was considered to be the main factor responsible by the CSF protein pattern which was found.