Nature Communications (Jun 2022)
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells
- Norio Kobayashi,
- Hiroaki Okae,
- Hitoshi Hiura,
- Naoto Kubota,
- Eri H. Kobayashi,
- Shun Shibata,
- Akira Oike,
- Takeshi Hori,
- Chie Kikutake,
- Hirotaka Hamada,
- Hirokazu Kaji,
- Mikita Suyama,
- Marie-Line Bortolin-Cavaillé,
- Jérôme Cavaillé,
- Takahiro Arima
Affiliations
- Norio Kobayashi
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Hiroaki Okae
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Hitoshi Hiura
- Department of Bioscience, Faculty of Life Science, Tokyo University of Agriculture
- Naoto Kubota
- Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University
- Eri H. Kobayashi
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Shun Shibata
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Akira Oike
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Takeshi Hori
- Department of Biomechanics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
- Chie Kikutake
- Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University
- Hirotaka Hamada
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- Hirokazu Kaji
- Department of Biomechanics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
- Mikita Suyama
- Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University
- Marie-Line Bortolin-Cavaillé
- Molecular, Cellular and Developmental biology department (MCD), Centre de Biologie Intégrative (CBI), University of Toulouse, CNRS, UPS
- Jérôme Cavaillé
- Molecular, Cellular and Developmental biology department (MCD), Centre de Biologie Intégrative (CBI), University of Toulouse, CNRS, UPS
- Takahiro Arima
- Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30775-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Little is known about the epigenetic mechanisms of the first cell fate commitment in humans. Here, the authors show that activation of the miRNA cluster C19MC confers differentiation potential into trophoblast lineages on human embryonic stem cells.
