Pepsinogen and Serum IgG Detection Is a Valuable Diagnostic Method for <i>Helicobacter pylori</i> Infection in a Low-Prevalence Country: A Report from Sri Lanka
Dalla Doohan,
Kartika Afrida Fauzia,
Jeewantha Rathnayake,
Meegahalande Durage Lamawansa,
Langgeng Agung Waskito,
Vo Phuoc Tuan,
Azzaya Dashdorj,
Evariste Tshibangu Kabamba,
Bui Hoang Phuc,
Shamshul Ansari,
Junko Akada,
Takashi Matsumoto,
Tomohisa Uchida,
Takeshi Matsuhisa,
Yoshio Yamaoka
Affiliations
Dalla Doohan
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Kartika Afrida Fauzia
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Jeewantha Rathnayake
Department of Surgery, Teaching Hospital Peradeniya, University of Peradeniya, Kandy 20404, Sri Lanka
Meegahalande Durage Lamawansa
Department of Surgery, Teaching Hospital Peradeniya, University of Peradeniya, Kandy 20404, Sri Lanka
Langgeng Agung Waskito
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Vo Phuoc Tuan
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Azzaya Dashdorj
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Evariste Tshibangu Kabamba
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Bui Hoang Phuc
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Shamshul Ansari
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Junko Akada
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Takashi Matsumoto
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Tomohisa Uchida
Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
Takeshi Matsuhisa
Department of Gastroenterology, Tama Nagayama University Hospital, Nippon Medical School, Tokyo 206-8512, Japan
Yoshio Yamaoka
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan
The use of serum anti-Helicobacter pylori IgG and pepsinogen (PG) detection as a diagnostic method was evaluated in Sri Lanka. Gastric biopsies were performed (353 patients), and the prevalence of H. pylori infection was 1.7% (culture) and 2.0% (histology). IgG serology testing showed an area under the curve (AUC) of 0.922 (cut-off, 2.95 U/mL; specificity, 91.56%; sensitivity, 88.89%). Histological evaluation showed mild atrophy (34.3%), moderate atrophy (1.7%), metaplasia (1.7%), chronic gastritis (6.2%), and normal tissue (56%). The PGI/PGII ratio was significantly higher in H. pylori-negative patients (p p = 0.049 and p H. pylori IgG and PG assessment (ABC method) was performed (group B, 2.0%; group A, 92.1%). The new cut-off more accurately identified patients with metaplasia requiring follow-up (group B, 5.4%). Assessment of anti-H. pylori IgG and PG is valuable in countries with a low prevalence of H. pylori infection.
