The causes and development of inflammatory bowel disease (IBD) are not fully understood and can be influenced by various factors such as genetic, environmental, and immune system dysfunction. With chronicity, IBD requires long-term medication use. Therefore, strictly adhering to the prescribed treatment regimen is essential to prevent relapses and achieve remission. This review article evaluates the relationship between treatment adherence (also compliance) and quality of life (QoL) in patients with IBD. We conducted a literature search using databases such as PubMed, Scopus, Web of Science, Embase, and eLibrary to analyze scientific articles published between 2013 and 2023. We included articles that presented the results of assessing quality of life and/or adherence to treatment in patients with IBD. We excluded articles that evaluated patients with other concomitant conditions or provided incomplete data.