Nature Communications (Jul 2019)

PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway

  • Gu-Choul Shin,
  • Sung Ung Moon,
  • Hong Seok Kang,
  • Hyo-Sun Choi,
  • Hee Dong Han,
  • Kyun-Hwan Kim

DOI
https://doi.org/10.1038/s41467-019-11019-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the IRE1α-XBP1 branch of the UPR.