Nature Communications (Dec 2019)

T4SS-dependent TLR5 activation by Helicobacter pylori infection

  • Suneesh Kumar Pachathundikandi,
  • Nicole Tegtmeyer,
  • Isabelle Catherine Arnold,
  • Judith Lind,
  • Matthias Neddermann,
  • Christina Falkeis-Veits,
  • Sujay Chattopadhyay,
  • Mark Brönstrup,
  • Werner Tegge,
  • Minsun Hong,
  • Heinrich Sticht,
  • Michael Vieth,
  • Anne Müller,
  • Steffen Backert

DOI
https://doi.org/10.1038/s41467-019-13506-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.