TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis

Sneha Damal Villivalam; Dongjoo You; Jinse Kim; Hee Woong Lim; Han Xiao; Pete-James H. Zushin; Yasuo Oguri; Pouya Amin; Sona Kang

doi:10.1038/s41467-020-18054-y

Nature Communications (Aug 2020)

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis

Sneha Damal Villivalam,
Dongjoo You,
Jinse Kim,
Hee Woong Lim,
Han Xiao,
Pete-James H. Zushin,
Yasuo Oguri,
Pouya Amin,
Sona Kang

Affiliations

Sneha Damal Villivalam: Nutritional Sciences and Toxicology Department, University of California Berkeley
Dongjoo You: Nutritional Sciences and Toxicology Department, University of California Berkeley
Jinse Kim: Nutritional Sciences and Toxicology Department, University of California Berkeley
Hee Woong Lim: Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center Department of Pediatrics & Biomedical Informatics, University of Cincinnati
Han Xiao: Nutritional Sciences and Toxicology Department, University of California Berkeley
Pete-James H. Zushin: Nutritional Sciences and Toxicology Department, University of California Berkeley
Yasuo Oguri: UCSF Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of California
Pouya Amin: Nutritional Sciences and Toxicology Department, University of California Berkeley
Sona Kang: Nutritional Sciences and Toxicology Department, University of California Berkeley

DOI: https://doi.org/10.1038/s41467-020-18054-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Epigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogenic genes in mouse adipose tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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