Tregs in transplantation tolerance: role and therapeutic potential

Alexandra Cassano; Anita S. Chong; Maria-Luisa Alegre

doi:10.3389/frtra.2023.1217065

Frontiers in Transplantation (Aug 2023)

Tregs in transplantation tolerance: role and therapeutic potential

Alexandra Cassano,
Anita S. Chong,
Maria-Luisa Alegre

Affiliations

Alexandra Cassano: Department of Medicine, University of Chicago, Chicago, IL, United States
Anita S. Chong: Department of Surgery, University of Chicago, Chicago, IL, United States
Maria-Luisa Alegre: Department of Medicine, University of Chicago, Chicago, IL, United States

DOI: https://doi.org/10.3389/frtra.2023.1217065
Journal volume & issue: Vol. 2

Abstract

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CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and they play a role in cancer and transplantation settings by restraining immune responses. In this review, we describe evidence for the importance of Tregs in the induction versus maintenance of transplantation tolerance, discussing insights into mechanisms of Treg control of the alloimmune response. Further, we address the therapeutic potential of Tregs as a clinical intervention after transplantation, highlighting engineered CAR-Tregs as well as expansion of donor and host Tregs.

Published in Frontiers in Transplantation

ISSN: 2813-2440 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.frontiersin.org/journals/transplantation

About the journal

Abstract

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