Frontiers in Medicine (Jan 2022)
Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The “PINK-CO” Observational Study
- Luigi Vetrugno,
- Luigi Vetrugno,
- Alessia Sala,
- Alessia Sala,
- Daniele Orso,
- Daniele Orso,
- Francesco Meroi,
- Francesco Meroi,
- Sebastiano Fabbro,
- Enrico Boero,
- Francesca Valent,
- Gianmaria Cammarota,
- Stefano Restaino,
- Giuseppe Vizzielli,
- Rossano Girometti,
- Rossano Girometti,
- Maria Merelli,
- Carlo Tascini,
- Carlo Tascini,
- Tiziana Bove,
- Tiziana Bove,
- Lorenza Driul,
- Lorenza Driul,
- The PINK-CO study investigators,
- Lisa Mattuzzi,
- Matteo Marin,
- Natascia D'Andrea,
- Victor Zanini,
- Michele Divella,
- Tommaso Occhiali,
- Elisa Barbui,
- Enrica Codutti,
- Elisa Fosca,
- Michela Nanino,
- Giuliana Scaiella,
- Paola Berchialla
Affiliations
- Luigi Vetrugno
- Department of Medicine, University of Udine, Udine, Italy
- Luigi Vetrugno
- Department of Anesthesia and Intensive Care Medicine, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Alessia Sala
- Department of Medicine, University of Udine, Udine, Italy
- Alessia Sala
- Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Daniele Orso
- Department of Medicine, University of Udine, Udine, Italy
- Daniele Orso
- Department of Anesthesia and Intensive Care Medicine, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Francesco Meroi
- Department of Medicine, University of Udine, Udine, Italy
- Francesco Meroi
- Department of Anesthesia and Intensive Care Medicine, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Sebastiano Fabbro
- Department of Medicine, University of Udine, Udine, Italy
- Enrico Boero
- Anesthesia and Intensive Care Unit, San Giovanni Bosco Hospital, Turin, Italy
- Francesca Valent
- Department of Epidemiology and Public Health, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Gianmaria Cammarota
- Department of Anesthesia and Intensive Care Medicine, University of Perugia, Perugia, Italy
- Stefano Restaino
- Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Giuseppe Vizzielli
- Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Rossano Girometti
- Department of Medicine, University of Udine, Udine, Italy
- Rossano Girometti
- Department of Radiology, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Maria Merelli
- Department of Infectious Diseases, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Carlo Tascini
- Department of Medicine, University of Udine, Udine, Italy
- Carlo Tascini
- Department of Infectious Diseases, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Tiziana Bove
- Department of Medicine, University of Udine, Udine, Italy
- Tiziana Bove
- Department of Anesthesia and Intensive Care Medicine, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- Lorenza Driul
- Department of Medicine, University of Udine, Udine, Italy
- Lorenza Driul
- Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
- The PINK-CO study investigators
- Lisa Mattuzzi
- Matteo Marin
- Natascia D'Andrea
- Victor Zanini
- Michele Divella
- Tommaso Occhiali
- Elisa Barbui
- Enrica Codutti
- Elisa Fosca
- Michela Nanino
- Giuliana Scaiella
- Paola Berchialla
- DOI
- https://doi.org/10.3389/fmed.2021.768261
- Journal volume & issue
-
Vol. 8
Abstract
ObjectiveTo analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients.DesignA single-center observational retrospective study from October 31, 2020 to March 31, 2021.SettingDepartment of Ob/Gyn at the University-Hospital of Udine, Italy.ParticipantsPregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19.ExposureLung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations.Main OutcomeReporting LUS findings and LUS score characteristics.ResultsSymptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0).ConclusionLung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge.Study RegistrationClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
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