Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

Pelin Saglam-Metiner; Utku Devamoglu; Yagmur Filiz; Soheil Akbari; Goze Beceren; Bakiye Goker; Burcu Yaldiz; Sena Yanasik; Cigir Biray Avci; Esra Erdal; Ozlem Yesil-Celiktas

doi:10.1038/s42003-023-04547-1

Communications Biology (Feb 2023)

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

Pelin Saglam-Metiner,
Utku Devamoglu,
Yagmur Filiz,
Soheil Akbari,
Goze Beceren,
Bakiye Goker,
Burcu Yaldiz,
Sena Yanasik,
Cigir Biray Avci,
Esra Erdal,
Ozlem Yesil-Celiktas

Affiliations

Pelin Saglam-Metiner: Department of Bioengineering, Faculty of Engineering, Ege University
Utku Devamoglu: Department of Bioengineering, Faculty of Engineering, Ege University
Yagmur Filiz: Department of Bioengineering, Faculty of Engineering, Ege University
Soheil Akbari: Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus
Goze Beceren: Department of Bioengineering, Faculty of Engineering, Ege University
Bakiye Goker: Department of Medical Biology, Faculty of Medicine, Ege University, Bornova
Burcu Yaldiz: Department of Bioengineering, Faculty of Engineering, Ege University
Sena Yanasik: Department of Bioengineering, Faculty of Engineering, Ege University
Cigir Biray Avci: Department of Medical Biology, Faculty of Medicine, Ege University, Bornova
Esra Erdal: Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus
Ozlem Yesil-Celiktas: Department of Bioengineering, Faculty of Engineering, Ege University

DOI: https://doi.org/10.1038/s42003-023-04547-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 18

Abstract

Read online

Two engineering approaches, a rotating cell culture system (RCCS) and microfluidic platform (µ-platform), are presented with the goal of improving harvestability, scalability, reproducibility and survival of human brain organoids in long term culture.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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