G3: Genes, Genomes, Genetics (Sep 2021)
A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers
Abstract
AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy resistance, and tumor recurrence. To determine whether the frequent overexpression of MELK can be exploited in therapy, we performed a high-throughput screen using a library of Saccharomyces cerevisiaeLAG2HDA3LAG2HDA3HDA1HDA3