Frontiers in Chemistry (Apr 2022)
Research Advances on Matrine
- Xiao-Ying Sun,
- Li-Yi Jia,
- Zheng Rong,
- Xin Zhou,
- Lu-Qi Cao,
- Ai-Hong Li,
- Meng Guo,
- Jie Jin,
- Yin-Di Wang,
- Ling Huang,
- Yi-Heng Li,
- Zhong-Jing He,
- Long Li,
- Rui-Kang Ma,
- Yi-Fan Lv,
- Ke-Ke Shao,
- Juan Zhang,
- Hui-Ling Cao,
- Hui-Ling Cao,
- Hui-Ling Cao,
- Hui-Ling Cao
Affiliations
- Xiao-Ying Sun
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Li-Yi Jia
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Zheng Rong
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Xin Zhou
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Lu-Qi Cao
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Ai-Hong Li
- Shaanxi Key Laboratory of Chinese Herb and Natural Drug Development, Medicine Research Institute, Shaanxi Pharmaceutical Holding Group Co., LTD, Xi’an, China
- Meng Guo
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Jie Jin
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Yin-Di Wang
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Ling Huang
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Yi-Heng Li
- College of Life Sciences, Northwest University, Xi’an, China
- Zhong-Jing He
- College of Life Sciences, Northwest University, Xi’an, China
- Long Li
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Rui-Kang Ma
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Yi-Fan Lv
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Ke-Ke Shao
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Juan Zhang
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Hui-Ling Cao
- College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China
- Hui-Ling Cao
- Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
- Hui-Ling Cao
- Shaanxi Key Laboratory of Chinese Herb and Natural Drug Development, Medicine Research Institute, Shaanxi Pharmaceutical Holding Group Co., LTD, Xi’an, China
- Hui-Ling Cao
- College of Life Sciences, Northwest University, Xi’an, China
- DOI
- https://doi.org/10.3389/fchem.2022.867318
- Journal volume & issue
-
Vol. 10
Abstract
Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors. The review introduced recent research progresses on extraction, synthesis and derivatization of Matrine. The summary focused on the latest research advances of Matrine on anti-atherosclerosis, anti-hypertension, anti-ischemia reperfusion injury, anti-arrhythmia, anti-diabetic cardiovascular complications, anti-tumor, anti-inflammatory, anti-bacterium, anti-virus, which would provide new core structures and new insights for new drug development in related fields.
Keywords
