Nature Communications (Jun 2018)

Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy

  • Alvaro Gomariz,
  • Patrick M. Helbling,
  • Stephan Isringhausen,
  • Ute Suessbier,
  • Anton Becker,
  • Andreas Boss,
  • Takashi Nagasawa,
  • Grégory Paul,
  • Orcun Goksel,
  • Gábor Székely,
  • Szymon Stoma,
  • Simon F. Nørrelykke,
  • Markus G. Manz,
  • César Nombela-Arrieta

DOI
https://doi.org/10.1038/s41467-018-04770-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The bone marrow microenvironment modulates haematopoiesis, stem cell maintenance and differentiation. Here, the authors use 3D microscopy to map the topography of haematopoietic stem cell niche stromal components.