Cardioprotective effect of cycloalliin in isoproterenol-induced myocardial infarction in albino rats: A mechanistic study

Abstract

Necrosis of the myocardium due to imbalance between coronary blood supply and oxygen demand of the myocardial tissue promotes the evolution of acute myocardial infarction (MI). Onions are considered a rich source of medicinal compounds, of which cycloalliin (CYC), a sulfur containing imino compound with a cyclic structure, has been been extensively reported to exhibit various pharmacological activities. The present study aimed to elucidate the protective effect of cycloalliin in isoproternol (ISO)-induced myocardial infarction in male albino Wistar rats. Results of our investigation showed that treatment with CYC (10 mg/kg) significantly elevated both (+) and (−) left ventricular delta pressure/delta time (LVdP/dt) and decreased left ventricular end diastolic pressure LVEDP compared to the isoproterenol-treated group. The level of TBARS was significantly increased in the ISO-treated group. This was accompanied by diminished myocardial creatine kinase-MB (CKMB) and lactate dehydrogenase (LDH) activities when compared with the control group (p<0.001). In CYC-treated groups, glutathione (GSH) activity was improved significantly (p<0.05) in comparison to the ISO-treated group. Treatment with CYC showed no sign of alteration in myocardial fibers.

Keywords

• cardioprotective effect
• cycloalliin
• isoproterenol-induced myocardial infarction
• antioxidants
• hemodynamic functions