Cancer Management and Research (Jun 2018)

Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population

  • Li C,
  • Wang X,
  • Li Y,
  • Zhang X,
  • Sun M,
  • Liu S,
  • Sun L,
  • Shi L,
  • Yao Y

Journal volume & issue
Vol. Volume 10
pp. 1487 – 1495

Abstract

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Chuanyin Li,1,* Xiaona Wang,1,* Yingfu Li,2 Xinwen Zhang,1 Mingbo Sun,1 Shuyuan Liu,1 Le Sun,3 Li Shi,1 Yufeng Yao1 1Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China; 2Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical University, Kunming 650032, China; 3Kunming Medical University, Kunming 650032, China *These authors contributed equally to this work Background: Recent studies have revealed that the TERT gene plays crucial roles in cancer initiation and development. Genome-wide analysis studies and case-control studies have demonstrated that polymorphisms in the TERT gene are associated with various cancers.Materials and methods: In the current study, we analyzed the associations of eight single nucleotide polymorphisms (SNPs) in the TERT gene with non-small cell lung cancer (NSCLC) in a Chinese Han population. A total of 467 NSCLC patients and 526 healthy individuals were recruited for SNP genotyping using a TaqMan assay. Results: Our results revealed that the allelic frequencies of rs2853677 and rs2853691 were significantly different between the NSCLC and control groups (P=0.004 and 0.001, respectively). Moreover, the T allele of rs2853677 and the A allele of rs2853691 might be the protective factors against NSCLC (OR=0.766; 95%CI: 0.639–0.918 and OR=0.714; 95%CI: 0.584–0.875, respectively). Additionally, stratified association analysis of the eight SNPs with the different pathological NSCLC stages (I+II and III+IV) and different pathological types (adenocarcinoma and squamous cell carcinoma) revealed that none of the SNPs were significantly different between patients with different pathological stages and pathological types.Conclusion: Our results indicated that rs2853677 and rs2853691 in the TERT gene might be associated with NSCLC in this Chinese Han population. Keywords: TERT gene, polymorphisms, lung cancer, Chinese Han population

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