CORTISOL LEVEL CONTROL AS A COMPONENT OF INTEGRATED ANESTHESIOLOGICAL MONITORING IN PATIENTS WITH TRAUMATIC BRAIN INJURY

Abstract

Objective. Assessment of the dynamics of cortisol in the serum as a criterion for the effectiveness of treatment of patients with traumatic brain injury (TBI). Material and methods. Of the 42 patients operated because of TBI, two groups were formed. Group 1 – 36 patients with a favorable outcome, group 2 – 6 patients with an unfavorable outcome. Comparison of cortisol between the groups was made at 4 stages of the study. Results. The value of cortisol in groups 1 and 2 the initial one was 533.2 (378.1; 860.0), 2097.3 (866.9; 2568.5) nmol /l, respectively; when removing the hematoma – 432.5 (258.8; 897.8), 1592.8 (1095.9; 3586.6) nmol /l; the end of the operation – 433.0 (218.0; 1021.5), 1183.2 (816.7; 2071.38) nmol /l; after surgery – 493.5 (351.6; 880.9), 1449.8 (1334.5; 2141.2) nmol /l. At all stages, p <0.05. Conclusions. In patients with fatal TBI, high serum cortisol values were detected at all stages of the study.

Keywords

• cortisol
• traumatic brain injury
• neuroanesthesiology
• scalp nerve block