Archives of Biological Sciences (Jan 2014)

The role of single nucleotide polymorphisms of cytokine genes in viral infections

  • Ćupić Maja,
  • Pravica Vera,
  • Lazarević Ivana,
  • Banko Ana,
  • Karalić Danijela,
  • Tasić Dijana,
  • Jovanović Tanja

DOI
https://doi.org/10.2298/ABS1402595C
Journal volume & issue
Vol. 66, no. 2
pp. 595 – 600

Abstract

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Gene polymorphisms result from evolutionary processes representing mutations that survive in the population with a frequency higher than 1%. The most investigated type of gene polymorphisms are single nucleotide polymorphisms (SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney graft CMV-seropositive recipients have an impact on a clinical events in cytomegalovirus (CMV) disease. Constitutive -308 G/A TNF-α polymorphism (rs1800629) is related to the susceptibility of HR-HPV-associated cervical dysplasia and cancer. SNP located 3 kb upstream of the IL- 28B gene (rs12979860) seems to be the strongest host genetic predictor of sustained virologic response (SVR) in hepatitis C genotype 1 patients. It is very important to identify viral and host genetic markers that may facilitate the risk of developing viral disease or some viral-associated cancers. In addition, these markers could be useful in the choice of effective treatments and preventive strategies against virally induced infection. [Projekat Ministarstva nauke Republike Srbije, br. 175073 i br. 175038]

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