Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism

Abstract

Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis.

Keywords

• autophagy
• branched ubiquitination
• vps34
• liver steatosis
• protein quality control