Cancer Management and Research (Oct 2021)

Simple Hysterectomy for Patients with Stage IA2 Cervical Cancer: A Retrospective Cohort Study

  • Liu Q,
  • Xu Y,
  • He Y,
  • Du Y,
  • Zhang Q,
  • Jia Y,
  • Zheng A

Journal volume & issue
Vol. Volume 13
pp. 7823 – 7832

Abstract

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Qing Liu,1 Yu Xu,2– 4 Yuedong He,2,3 Yi Du,2,3 Qianwen Zhang,2 Ya Jia,2 Ai Zheng2 1School of Medical and Life Science, Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, People’s Republic of China; 4West China Medical Center, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Yu XuDepartment of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of ChinaEmail [email protected]: The purpose of this study was to compare long-term survival outcomes of simple hysterectomy versus radical hysterectomy in stage IA2 cervical cancer.Methods: A total of 440 patients who underwent simple hysterectomy (SH group) or radical hysterectomy (RH group) between 2014 and 2019 were included in this study. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan–Meier method and compared by the Log rank test. The Cox proportional hazards regression model was employed to control for confounders.Results: There were 258 patients in the RH group and 182 patients in the SH group. The two groups had similar 5-year DFS rate (89.25% vs 91.14%, P=0.562) and 5-year OS rate (95.71% vs 94.76%, P=0.482). Multivariable analysis showed that simple hysterectomy was not independently associated with poorer DFS (aHR, 1.608; 95% CI, 0.640– 4.041; P=0.312) and OS (aHR, 1.122; 95% CI, 0.319– 3.493; P=0.858) than radical hysterectomy for women with stage IA2 cervical cancer.Conclusion: For stage IA2 cervical cancer, a simple hysterectomy is safe and effective. Further studies are needed to testify against our findings.Keywords: cervical cancer, stage IA2, simple hysterectomy, overall survival, disease-free survival

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