Post-transplantation diabetes mellitus: an overview

Abstract

This review presents an analysis of clinical and experimental studies related to post-transplantation diabetes mellitus (PTDM) ? a specific complication after solid organ transplantation. A search of the databases eLibrary, PubMed and Scopus using the keywords ?posttransplantation diabetes mellitus?, ?new onset diabetes after transplantation?, ?transplantation? and ?immunosuppression? yielded in 523 results, including four from Russian literature (one original research manuscript). The analysis included original research, reviews, meta-analyses and monographs published not before 2005 in Russian and English. A total of 60 relevant original researches and reviews were included in this review. Diagnostic criteria, disease risk factors and potential pathogenic mechanisms were all considered. The mechanisms of the diabetogenic effect of modern immunosuppressive drugs were analysed. The principles of pre- and post-transplantation screening for PTDM and optimal management strategies for patients with PTDM are presented. The current controversial issues concerning the various aspects of PTDM are discussed.

Keywords

• post-transplantation diabetes mellitus
• transplantation
• new onset diabetes
• immunosuppressive agents
• cytochrome p-450
• hypoglycaemic agents