Bilateral inguinal HPV-related squamous cell carcinomas with warty-basaloid features: An unusual presentation in a non-penile location

Abstract

The relevance of human papillomavirus (HPV)-related features in cutaneous, non-anogenital SCC is not known and not incorporated into current diagnostic categories and treatment algorithms. Here, we describe the case of a 78-year-old male with bilateral inguinal warty-basaloid carcinoma, which is an HPV-related SCC that, in men, has been described only in a penile location. The patient underwent surgical excision without lymphadenectomy and declined radiation therapy due to concerns of poor wound healing. Adjuvant chemotherapy was not offered given the patient's Stage IV chronic kidney disease and undefined degree of benefit in the absence of concurrent radiotherapy. We therefore opted for close follow up and surveillance with PET/CT imaging and full body skin exams. The patient also received HPV vaccination. No clinical evidence of recurrence or metastasis was apparent at 6 months following initial excision. The identification of HPV-associated cutaneous SCC and correlation with patient outcomes is necessary to evaluate the prognostic significance of these features and to clarify the role of different treatment strategies in this setting.

Keywords

• Human papilloma virus
• Squamous cell carcinoma
• Cutaneous oncology
• Warty-basaloid