Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Yejie Shi; Lili Zhang; Hongjian Pu; Leilei Mao; Xiaoming Hu; Xiaoyan Jiang; Na Xu; R. Anne Stetler; Feng Zhang; Xiangrong Liu; Rehana K. Leak; Richard F. Keep; Xunming Ji; Jun Chen

doi:10.1038/ncomms10523

Nature Communications (Jan 2016)

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Yejie Shi,
Lili Zhang,
Hongjian Pu,
Leilei Mao,
Xiaoming Hu,
Xiaoyan Jiang,
Na Xu,
R. Anne Stetler,
Feng Zhang,
Xiangrong Liu,
Rehana K. Leak,
Richard F. Keep,
Xunming Ji,
Jun Chen

Affiliations

Yejie Shi: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Lili Zhang: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Hongjian Pu: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Leilei Mao: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Xiaoming Hu: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Xiaoyan Jiang: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Na Xu: State Key Laboratory of Medical Neurobiology, Institute of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University
R. Anne Stetler: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Feng Zhang: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Xiangrong Liu: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine
Rehana K. Leak: Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University
Richard F. Keep: Department of Neurosurgery, University of Michigan
Xunming Ji: China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University
Jun Chen: Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/ncomms10523
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 18

Abstract

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Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke. Here, the authors identify an early, MMP-independent BBB breakdown mechanism caused by rapid cytoskeletal rearrangements in endothelial cells, which could be inhibited by ADF.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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