International Journal of Nephrology (Jan 2018)

A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus

  • Miguel Ángel Gómez-Sámano,
  • Paloma Almeda-Valdes,
  • Daniel Cuevas-Ramos,
  • María Fernanda Navarro-Flores,
  • Héctor Donaldo Espinosa-Salazar,
  • Mayela Martínez-Saavedra,
  • Jefsi Argelia León-Domínguez,
  • Víctor Manuel Enríquez-Estrada,
  • Ana Laura López-González,
  • Ana Laura Sarmiento-Moreno,
  • Lucero Alejandra Rivera-González,
  • Óscar Alfredo Juárez-León,
  • Bernardo Pérez-González,
  • Yessica Ávila-Palacios,
  • Lineth Sigala-Pedroza,
  • Eira Huerta-Ávila,
  • María Angelina Vargas-Álvarez,
  • Carlos Sánchez-Jaimes,
  • Mariana Cárdenas-Vera,
  • Roopa Mehta,
  • Manuel Alejandro López-Flores A La Torre,
  • Iliana Manjarrez-Martínez,
  • Griselda Xochitl Brito-Córdova,
  • Julia M. Zuarth-Vázquez,
  • Arturo Vega-Beyhart,
  • Guadalupe López-Carrasco,
  • Richard J. Johnson,
  • Francisco Javier Gómez-Pérez

DOI
https://doi.org/10.1155/2018/5459439
Journal volume & issue
Vol. 2018

Abstract

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The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (≥ 25 g/day). Complete clinical and biochemical evaluations were performed, including anthropometric variables and a 24-hour urine collection for albuminuria determination. One hundred and thirty-six subjects were analyzed in this study. We found a positive significant association between daily fructose intake and albuminuria (ρ= 0.178, p=0.038) in subjects with type 2 diabetes mellitus. Other variables significantly associated with albuminuria were body mass index (BMI) (ρ= 0.170, p=0.048), mean arterial pressure (MAP) (ρ= 0.280, p=0.001), glycated hemoglobin (A1c) (ρ= 0.197, p=0.022), and triglycerides (ρ= 0.219, p=0.010). After adjustment for confounding variables we found a significant and independent association between fructose intake and albuminuria (β= 13.96, p=0.006). We found a statistically significant higher albuminuria (60.8 [12.8-228.5] versus 232.2 [27.2-1273.0] mg/day, p 0.002), glycated hemoglobin (8.6±1.61 versus 9.6±2.1 %), p= 0.003, and uric acid (6.27±1.8 versus 7.2±1.5 mg/dL), p=0.012, in the group of high fructose intake versus the group with low fructose intake, and a statistically significant lower creatinine clearance (76.5±30.98 mL/min versus 94.9±36.8, p=0.014) in the group with high fructose intake versus the group with low fructose intake. In summary we found that a higher fructose intake is associated with greater albuminuria in subjects with T2DM.